Can You Answer These 4 Sample USMLE Step 2 CK Practice Questions?

If you’re preparing for your USMLE Step 2 CK exam, you may be overwhelmed by all the topics you have to prepare for. It can feel like a small, vital step on a long road to your goal of becoming a doctor. The best way to prepare for these exams is by getting really comfortable with practice questions. We’ve chosen 4 highly rated questions from the BoardVitals USMLE Step 2 CK Practice Question Bank. Can you answer them correctly?

How did you do? Whether you aced them all or missed a few, you still can use more practice.

The USMLE Step 2 CK exam lasts approximately nine hours and consists of sixteen 30-minute blocks. In 2025, the pass rate for Step 2 was 97% among all test takers. According to the USMLE Step 2CK Content Outline, the topics covered on the exam are broken down as follows:

Table 1: Step 2 CK Test Specifications 

• Nutrition: 15–20%
• Social Sciences: Legal/Ethical Issues & Professionalism/Systems-based Practice & Patient Safety: 10-15%
• Renal & Urinary System & Reproductive Systems: 7–13%
• Cardiovascular System: 6–12%
• Musculoskeletal System/Skin & Subcutaneous Tissue: 6–12%
• Behavioral Health: 5–10%
• Blood & Lymphoreticular/Immune Systems: 5-10%
• Gastrointestinal System: 5–10%
• Nervous System & Special Senses: 5–10%
• Respiratory System: 5–10%
• Multisystem Processes & Disorders: 4–8%
• Endocrine System: 3–7%
• Pregnancy, Childbirth & the Puerperium: 3–7%
• Biostatistics & Epidemiology/Population Health/Interpretation of Medical Literature: 3–5%
• Human Development: 2–4%

Table 2: Step 2 CK Physician Task/Competency Specifications 

• Patient Care: Diagnosis 16–20%
• Patient Care: Laboratory/Diagnostic Studies 13–17%
• Patient Care: Mixed Management 12–16%
• Patient Care: Pharmacotherapy 8–12%
• Patient Care: Clinical Interventions 6–10%
• Patient Care: Health Maintenance/Disease Prevention 5–10%
• Patient Care: Prognosis/Outcome 5–9%
• Systems-Based Practice & Patient Safety 5–7%
• Professionalism 5–7%
• Practice-Based Learning & Improvement 3–5%

Table 3: Step 2 CK Clinical Science Specifications

• Medicine: 55–65%
• Pediatrics: 17–27%
• Obstetrics & Gynecology: 10–20%
• Psychiatry: 10–15%
• Surgery: 5–15%

BoardVitals USMLE Step 2 CK Practice Question Bank has more than 1,400 questions targeted to the USMLE Step 2 CK Board Exam. Click here for a free trial, and save 10% when you use promo code QUIZ10at checkout..

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