Scaling Process Intensification from Seed Train to Production in Biomanufacturing

Process intensification strategies promise to reduce biomanufacturing costs and increase productivity. Strategies include intensifying the seed train—increasing inoculation density and thereby reducing the number of cell expansion steps—or intensifying the production stage bioreactor process itself. However, many promising strategies fail to translate during scale-up due to platform inconsistencies, oxygen transfer limitations, or poor system integration.

In this GEN webinar, experts from Sartorius will discuss how a modular, single-use portfolio enables process intensification from seed train to production. During the webinar, they will present high cell-density perfusion data in both rocking-motion and stirred-tank reactor (STR) platforms and introduce an intensified sparger for STRs that almost doubles oxygen transfer, delivering corresponding gains in peak cell density. Key takeaways from the webinar include:

• Details of a scalable portfolio that leverages consistent vessel geometry and integrated cell retention devices
• How perfusion strategies and results translate from development to manufacturing
• Economic and environmental benefits of transitioning from classic to intensified process technologies

A live Q&A will follow the presentation, offering you a chance to pose questions to our expert panelists.

Produced with support from: